Cervical Cancer Factsheet

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چکیده

The surface layer of the cervix is made up of squamous and columnar epithelial cells. The area where these two cells meet around the opening of the cervix that leads on to the endocervical canal is called the transformation zone or squamo-columnar junction. It is in this area of the cervix where cervical cells are most likely to become cancerous. Approximately 75% of cervical cancers are squamous in origin, developing from the flat epithelial cells in the vicinity of the transformation zone. About 15% are adenocarcinomas that develop from the glandular epithelial cells which line the cervical canal (endocervix). Other less common variants of squamous and glandular carcinomas are recognised. Rare types of non-epithelial tumours account for less than 1% and include lymphomas and sarcomas. Cancer of the cervix is preceded by the development of abnormal epithelial cells known as cervical intraepithelial neoplasia (CIN) or dysplasia. CIN is classified into three grades (CIN 1, 2 and 3) depending upon the extent of epithelial involvement. CIN has the potential to develop into cancer if left untreated. Cervical screening (the smear test) is designed to detect early changes (dyskaryosis) in the cells of the transformation zone. (More details of this and other screening programmes are outlined on Factsheet No. 15 within this series). Sources: CancerBacup Website and Cancer Link Website

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تاریخ انتشار 2002